Description

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What is Tibsovo?

Tibsovo (ivosidenib) is a once-daily oral medication that targets a specific gene mutation called the isocitrate dehydrogenase-1 (IDH1) mutation, which can affect your bone marrow. An IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in blood and bone marrow disorders such as acute myeloid leukemia (AML). Buy Tibsovo For Sale In USA

Tibsovo may be used to treat adults with a confirmed susceptible IDH1 mutation with:

• newly diagnosed acute myeloid leukemia (AML) either in combination with azacitidine or as monotherapy in patients 75 years or older who have comorbidities that preclude the use of intensive induction chemotherapy
• relapsed or refractory AML
• relapsed or refractory myelodysplastic syndromes
• bile duct cancer (cholangiocarcinoma) that has progressed or has spread to other parts of the body (metastatic) after treatment with other medicine.

Tibsovo targets the IDH1 mutation. In regular cells, the IDH1 gene produces the IDH1 protein, involved in normal cellular chemical processes. However, when the IDH1 gene is modified due to a genetic mutation, it leads to an abnormal version of the IDH1 protein and other substances such as the oncometabolite, D-2-hydroxyglutarate (2-HG). Tibsovo decreases levels of 2-HG, reducing blast counts and increasing levels of mature myeloid cells. Blasts are undeveloped bone marrow cells that will later mature into red blood cells, white blood cells, or blood-clotting platelets. They are typically absent in the bloodstream, and their presence signals a bone marrow issue, such as myelodysplastic syndrome. Buy Tibsovo For Sale In USA

Up to 20% of people with cholangiocarcinoma, and 6% to 10% of people with AML have the IDH1 mutation.

Tibsovo was first FDA-approved on July 20, 2018.

Warnings

Tibsovo can cause irregular heartbeats that can be life-threatening, such as QTc interval prolongation. The risk is higher in people who also take other medications that cause QTc prolongation. Your healthcare provider will check the electrical activity of your heart with a test called an electrocardiogram (ECG) before and during treatment. Tibsovo For Sale online

Guillain-Barré Syndrome has occurred in 0.8% of patients treated with Tibsovo. Tell your doctor if you develop weakness on one or both sides of your body, sensory alterations, burning or prickling sensations, or difficulty breathing.

Tibsovo can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. It can occur within 1 day to 3 months after you start taking the treatment. Seek medical help right away if you have symptoms of differentiation syndrome: fever, dizziness, cough, trouble breathing, swelling, rapid weight gain, rash, or decreased urination. Buy Tibsovo For Sale In USA

It is not known if Tibsovo is safe and effective in children.