Description

Buy Mektovi For Sale In USA

What is Mektovi?

Mektovi (binimetinib) is an oral kinase inhibitor that may be used in combination with encorafenib for the treatment of adults with: Buy Mektovi For Sale In USA

• unresectable or metastatic melanoma with a confirmed BRAF V600E or V600K mutation
• metastatic non-small cell lung cancer (NSCLC) with a confirmed BRAF V600E mutation.

Mektovi (binimetinib) is an oral kinase inhibitor that may be used in combination with encorafenib for the treatment of adults with: Buy Mektovi For Sale In USA

• unresectable or metastatic melanoma with a confirmed BRAF V600E or V600K mutation
• metastatic non-small cell lung cancer (NSCLC) with a confirmed BRAF V600E mutation.

Mektovi is a reversible inhibitor of two proteins, mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2. These are upstream regulators of the extracellular signal-related kinase (ERK) pathway and blocking them results in an inhibition of extracellular signal-related kinase (ERK) phosphorylation as well as the viability and MEK-dependent phosphorylation of BRAF-mutations. A BRAF mutation is a spontaneous change in the BRAF gene that makes it work incorrectly, turning on the protein and keeping it on. This means certain cells get ongoing signals to keep dividing and no instructions on when to stop, leading to the development of a tumor. It is given together with encorafenib which targets a different kinase in the RAS/RAF/MEK/ERK pathway.

Roughly 50% of patients diagnosed with metastatic melanoma test positive for the BRAF mutation, and it is the most common genetic mutation in metastatic melanoma. BRAF mutations are rare in non-small cell lung cancer (NSCLC), occurring in 2% to 5% of cases.

Warnings

Although Mektovi is used to treat melanoma, it may increase your risk of developing other types of cancer including skin cancer when used in combination with encorafenib. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin or other symptoms. Your healthcare provider should check your skin before treatment, every 2 months during treatment, and for up to 6 months after you stop treatment to look for any new skin or other cancers.

Mektovi can harm an unborn baby. Do not use it if you are pregnant. Your doctor may conduct a pregnancy test before you start treatment if you are a woman of childbearing age. Use a non-hormonal form of birth control to prevent pregnancy while using Mektovi and for at least 30 days after your last dose. Buy Mektovi For Sale In USA

May not be suitable for patients with cardiomyopathy. Your healthcare provider will assess your left ventricular ejection fraction (LVEF) before initiating treatment, then after one month of treatment, and then every 2 to 3 months thereafter.

May cause liver toxicity when used in combination with encorafenib. Your healthcare provider will conduct liver function tests before treatment, and then monitor your liver function during treatment.

There is also a risk of major bleeding events, venous thromboembolism, interstitial lung disease, muscle toxicity, and eye toxicity such as uveitis (inflammation inside the eye), and retinopathy (disease of the retina). Your doctor may perform certain tests before starting treatment, and then monitor you throughout treatment.

It is not known if Mektovi is safe and effective in children.

Mektovi is not recommended to be used as a single agent. Buy Mektovi For Sale In USA