Description
What is Gliolan?
Gliolan is a powder to be made up into a solution to be taken by mouth. It contains the active substance 5-aminolevulinic acid hydrochloride (30 mg/ml). Buy GLIOLAN For Sale In USA
What is Gliolan used for?
Gliolan is used in adult patients with malignant glioma (a type of brain tumour). Gliolan helps surgeons to see the tumour more clearly during an operation to remove it from the brain.
Because the number of patients with malignant glioma is low, the disease is considered ‘rare’, and Gliolan was designated an ‘orphan medicine’ (a medicine used in rare diseases) on 13 November 2002.
The medicine can only be obtained with a prescription.
How is Gliolan used?
Gliolan should only be used by experienced brain surgeons who are familiar with surgery of malignant glioma, who have an in-depth knowledge of the anatomy of the brain, and who have completed a training course in surgery guided by fluorescence.
The recommended dose of Gliolan is 20 mg per kilogram body weight, taken two to four hours before the patient is anaesthetised. Gliolan powder should be dissolved in 50 ml tap water by a nurse or pharmacist before the patient drinks the solution. Gliolan should be used with caution in patients who have problems with their liver or kidneys. Buy GLIOLAN For Sale In USA
How does Gliolan work?
The active substance in Gliolan, 5-aminolevulinic acid, is a ‘sensitiser used in photodynamic therapy’. It is absorbed by cells in the body, where it is converted by enzymes into fluorescent chemicals, particularly protoporphyrin IX (PPIX). Since glioma cells take up more of the active substance and convert it more rapidly into PPIX, higher levels of PPIX accumulate in the cancer cells than in normal tissue. When illuminated under blue light of a specific wavelength, the PPIX in the tumour glows an intense red, while the normal brain tissue appears blue. This enables the surgeon to see the tumour more clearly during brain surgery and to remove it more accurately, sparing healthy brain tissue.
How has Gliolan been studied?
The effects of Gliolan were first tested in experimental models before being studied in humans.
However, because 5-aminolevulinic acid is a naturally occurring substance which is already used in some other conditions, the company also presented data from the published literature.
Gliolan has been studied in one main study involving 415 patients with malignant glioma who were about to undergo brain surgery to remove the tumour. The outcome of the operation was compared between patients taking Gliolan (operated under blue light) and that of patients who did not take any medicines to improve the visibility of the tumour (operated under normal white light). The main measures of effectiveness were the proportion of patients who had no visible tumour on a brain scan taken 72 hours after the operation, and the proportion who survived six months without the brain tumour coming back or getting bigger (‘progressing’). The brain scans were analysed by an expert who did not know whether the patients had received Gliolan or not. Buy GLIOLAN For Sale In USA
Reviews
There are no reviews yet.