Description

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What is Empaveli?

Empaveli (pegcetacoplan) is an immunosuppressant that is given by subcutaneous (under the skin) infusion, which may be used to treat adults with paroxysmal nocturnal hemoglobinuria (PNH). PNH is a rare acquired, life-threatening disease of the blood that is characterized by the destruction of red blood cells (hemolytic anemia), blood clots (thrombosis), and impaired bone marrow function. Buy Empaveli For Sale In USA

Empaveli works by binding to specific proteins in the complement system, which is a part of the immune system that enhances (or complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen’s cell membrane. Empaveli binds to complement protein C3 and prevents it from splitting into C3a and C3b. This helps to stop intravascular hemolysis (IVH or the destruction of red blood cells in the circulation) and extravascular hemolysis (EVH or the breakdown of red blood cells in the spleen, bone marrow, or liver by macrophages). Empaveli is the only treatment that targets C3 and may prevent both forms of red blood cell destruction (IVH and EVH). It works higher in the complement system than other treatments used for PNH. Buy Empaveli For Sale In USA

Empaveli was FDA approved on May 14, 2021 and is only approved to treat PNH.

Warnings

Empaveli can lower the ability of your immune system to fight infections and increase your risk of developing serious and life-threatening infections, including meningitis caused by encapsulated bacteria such as Streptococcus pneumoniae; Neisseria meningitidis, types A, C, W, Y, and B; and Haemophilus influenzae type B. You must be vaccinated against these bacteria at least 2 weeks before your first dose if you have not already had these vaccines. If your healthcare provider decides that urgent treatment with Empaveli is needed, you should receive the required vaccinations as soon as possible. Meningococcal infections may quickly become life-threatening and cause death if not recognized and treated early.

May cause infusion-related reactions or anaphylaxis which may be life-threatening. Seek immediate medical attention if you develop any of the following, difficulty breathing including shortness of breath and wheezing, swollen tongue or throat, feeling faint, rapid heart rate, skin reactions, including hives and itching, nausea or vomiting, confusion and anxiety, dizziness or fainting.

May interfere with laboratory tests, such as those that use silica reagents in coagulation panels (may cause an artificially prolonged activated partial thromboplastin time [aPTT]). Buy Empaveli For Sale In USA

Only available through a restricted program called the Empaveli REMS. Your healthcare provider must be a member of this program to be able to prescribe Empaveli and provide you with the necessary information and Patient Safety Card. Empaveli For Sale online

It is not known if Empaveli is safe and effective in children.