Description

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What is Besponsa?

Besponsa is an antineoplastic biological drug used to treat adults and children aged 1 year and older with a type of blood cancer called CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) (also known as acute lymphocytic leukemia). Buy Besponsa For Sale In USA

Besponsa is an antibody-drug conjugate – it uses an antibody to insert an anticancer drug directly into B-cell leukemia cells.

B-cells, which are also known as B-lymphocytes, are part of your immune system and usually help to fight infection. But in people with ALL, the B-cells grow and divide much faster than normal. The abnormal B-cells build up in the bone marrow where they are made, and then spread to the blood and other parts of the body causing ALL. The abnormal B-cells are not fully developed and don’t work properly. Buy Besponsa For Sale In USA

Besponsa uses a humanized immunoglobulin class G subtype 4 (IgG4) kappa antibody called inotuzumab to target a cytotoxic drug called calicheamicin to the leukemia cells.

Inotuzumab targets CD22, which is a sialoglycoprotein found on the surface of B-cells. CD22 regulates how B-cells function and proliferate. Inotuzumab delivers the anti-tumor antibiotic calicheamicin to the cancer cells, where it is internalized into the cells. Once inside the cell, calicheamicin is released and works by inducing DNA double-strand breaks, which cause the cancer cells to die. Besponsa For Sale

Besponsa was first approved by the US Food and Drug Administration in 2017. No biosimilars of Besponsa have been approved. Biosimilars are highly similar versions of the drug that are designed to have the same effect on a person, but they are not identical to the original version of the drug.

What is Besponsa used for?

Besponsa is a prescription medicine used to treat adults and children aged 1 year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL).

Important information

Besponsa use is linked to an increased risk of liver problems and death after stem cell transplant.

Besponsa can cause liver problems that can be severe, life-threatening, or fatal, including a condition called veno-occlusive disease (VOD). This condition can occur during treatment with Besponsa or following subsequent treatment with a stem cell transplant. This condition was more common in patients who had elevated liver tests or who received dual alkylating agents in preparation for their stem cell transplant. Patients may be at a higher risk of VOD if they: Buy Besponsa For Sale In USA

• Receive a stem cell transplant after treatment with Besponsa
• Have previously received a stem cell transplant
• Have ongoing or a history of liver problems
• Are of older age
• Received multiple treatments for their ALL before Besponsa
• Receive a greater number of Besponsa treatment cycles