Description

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What is Padcev?

Padcev (enfortumab vedotin) is an antibody-drug conjugate that is given as an intravenous infusion by a healthcare provider and may be used to treat adults with urothelial cancer, the most common type of bladder cancer that is locally advanced or has spread (metastasized) either: Buy Padcev For Sale In USA

• in combination with pembrolizumab (Keytruda)
• as a single agent in patients who have previously received an immunotherapy medicine and chemotherapy that contains platinum, OR who are not able to receive chemotherapy that contains the medicine cisplatin and have already received 1 or more prior lines of standard bladder cancer therapy.

Padcev is a conjugate medicine that contains two active parts: a human IgG1 kappa directed against Nectin-4 which is a protein located on the surface of cells and highly expressed in bladder cancer and MMAE (monomethyl auristatin E), which is a microtubule-disrupting agent that has been attached to the antibody via a protease-cleavable linker. After Padcev attaches to the surface of cancer cells expressing Nectin-4, it then enters the cells releasing MMAE. This causes the cells to stop dividing and programmed cell death (apoptosis), affecting the growth of the cancer. Padcev For Sale online

Padcev was first FDA-approved on December 18, 2019.

Warnings

Padcev can cause a severe or life-threatening skin rash including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Get emergency medical help if you have a worsening rash with itching, blistering, peeling, skin lesions that look like rings, fever or flu-like symptoms, swollen glands, or painful sores in your mouth, nose, throat, or genital area. Buy Padcev For Sale In USA

Padcev can cause high blood sugar (hyperglycemia) even if you have never had it before or if you are not diabetic. Severe hyperglycemia may be life-threatening. Your blood sugar may need to be checked often. Padcev should be withheld if blood glucose rises above is >250 mg/dL.

Severe and life-threatening fatal pneumonitis/interstitial lung disease (ILD) and peripheral neuropathy have been reported with Padcev. Your healthcare provider will monitor you for these.

Padcev can also cause dry eyes, vision changes, and other eye disorders. Your doctor will monitor you for these with periodic eye examinations and may tell you to use artificial-tear eye drops to help prevent dry eyes and other eye drops. Buy Padcev For Sale In USA

Infusion site reactions may also occur.

Padcev can cause fetal harm. Women of childbearing age and men with partners who could become pregnant should use effective contraception.

It is not known if this medicine is safe and effective in children.