Description

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What is Piqray?

Piqray (alpelisib) is used to treat breast cancer in men and postmenopausal women, that is HR-positive, HER2-negative, and is advanced or has spread to other parts of the body (metastatic). Piqray is a targeted therapy from a class of medicines called PI3K inhibitors (phosphoinositide 3-kinase inhibitors) and is sometimes called a kinase inhibitor. Buy Piqray For Sale In USA

Piqray is only used for breast cancer if it has a specific PIK3CA mutation (an abnormal “PIK3CA” gene) which your doctor will test you for. Piqray is given in combination with fulvestrant (Faslodex).

Piqray became an FDA-approved medicine on May 24, 2019, as the first PI3K Inhibitor for specific breast cancers. Another brand, alpelisib called Vijoice became an FDA-approved medicine on April 5, 2022, to treat specific patients with PIK3CA-Related Overgrowth Spectrum (PROS).

What is PI3K and PIK3CA?

PI3K is an enzyme involved in cellular functions such as cell growth, proliferation, differentiation, motility, and survival. PI3K is the short name for Phosphatidylinositol-3-kinase. Buy Piqray For Sale

PIK3CA is a small part of PI3K. PIK3CA is the short name for Phosphatidylinositol-3-kinase catalytic subunit alpha.

When there is a mutation in the PIK3CA gene, it can allow cancer cells to grow and survive, which results in tumors.

How does Piqray work?

Piqray works by blocking PIK3CA, so is used to treat breast cancer that has a specific genetic mutation in the PIK3CA gene. In breast cancer, the mutation in the PIK3CA gene results in the generation of tumors, Piqray works to block PI3K, which reduces breast cancer growth. The combination of Piqray and fulvestrant has an increased anti-tumor activity compared to either treatment alone.

What is Piqray used to treat?

Piqray is used to treat breast cancer in men and postmenopausal women if their cancer is:

• PIK3CA-mutated as detected by an FDA-approved test,
• advanced or metastatic breast cancer,
• cancer has progressed on or after an endocrine-based regimen,
• hormone receptor (HR)-positive,
• human epidermal growth factor receptor 2 (HER2)-negative, and
• treatment is used in combination with a hormone therapy fulvestrant (Faslodex), used for certain types of breast cancer treatment. Buy Piqray For Sale In USA

Piqray side effects

Common Piqray side effects may include:

• nausea, vomiting;
• loss of appetite, weight loss;
• feeling weak or tired;
• mouth sores;
• rash;
• hair loss; or
• abnormal blood tests.

Serious side effects:

Get emergency medical help if you have signs of an allergic reaction (hives, warmth or tingling, difficulty breathing, fast heartbeats, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Piqray may cause other serious side effects. Call your doctor at once if you have:

• chest pain, cough, feeling short of breath;
• severe or ongoing diarrhea;
• blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
• pale skin, unusual tiredness, cold hands and feet;
• little or no urination; or
• high blood sugar with symptoms of increased thirst, increased urination, dry mouth, fruity breath odor, confusion, hunger, weight loss;

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.